Mesophotic coral ecosystems (MCEs) are found on the insular and continental slopes of Caribbean islands and comprise mainly scleractinian corals, sponges and macroalgae. These species provide habitat for a highly diverse and specialized crustacean fauna. A new genus and species of the family Louriniidae is described from samples taken from an MCE in south-west Puerto Rico. The new taxa can be diagnosed by: body elongate, almost cylindrical and with inconspicuous podoplean boundary between prosome and urosome; double genital somite with a discontinuous chitinized cuticular ridge; telson short with rectangular anal operculum; furca short; rostrum sinusoidal, well defined at the base; antennules 7-segmented with aesthetasc on the fourth segment; antenna with a brush-like basal seta and an abexopodal seta, exopod 1-segmented with 2 setae; endopod with 7 elements (1 geniculate seta and 1 modified inner spine); maxilliped well developed, prehensile, composed of syncoxa, basis, one segmented endopod and one claw-like apical seta; leg 1 endopod 3-segmented, first segment with a modified inner seta; legs 2, 3 and 4 with 2-segmented endopod with inner seta on the first segment; leg 5 basendopod fused, well developed with 4 setae, exopod well developed, with 5 setae; leg 6 represented by a single seta; and genital slits wide apart. The new genus and species can be confidently assigned to the family Louriniidae on the basis of the following synapomorphies: rostrum well-developed with rounded tip; antennule of female 7-segmented; mandible palp reduced; maxillule endopod and exopod absent; maxillae endopodite 2 represented by 3 setae; leg 5 basoendopod of female confluent, intercoxal sclerite absent, exopod 1-segmented; eggs retained in a single ventral egg sac; telson shorter than last urosomite; and furca short and with 6 setae.